Annotation

Overview

This tool allows you to find out what the sequence for the light and heavy variable regions are, as well as the sequence of the CDRs.

Inputs

• Sequence ID

• Sequence to annotate

• Return a numbering table as JSON string (true) or not (false) - default false

Outputs

• The sequence for the variable regions

• The sequence of the CDRs

Description

Annotation is an important tool for helping to locate the CDRs of an antibody. EMLy uses ANARCII to annotate antibody/TCR sequences and find out the chain types of the TCRs. ANARCII is an improvement on ANARCI as it uses Seq2Seq transformer architecture as opposed to an alignment step, meaning it is able to replicate the results of ANARCI while generalising to sequence types it could not have previously renumbered. The alignment step in ANARCI means the renumbered areas can change slightly depending on the set being aligned to, which ANARCII avoids.